function:May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the c-myc promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors.,similarity:Contains 6 C2H2-type zinc fingers.,subcellular location:In brains of Alzheimer disease patients, present in a plaque-like structures.,subunit:Interacts with BPTF.,tissue specificity:Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex and midfrontal cortex (at protein level).,
Nucleus . In brains of Alzheimer disease patients, present in a plaque-like structures.
Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex and midfrontal cortex (at protein level). ; [Isoform 1]: Expressed in the heart, brain, placenta, lung, liver, skeletal muscle and weakly expressed in the kidney (PubMed:1502157). Expressed in the joint synovium (PubMed:19583771).
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