catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Manganese. Only isoform A requires manganese.,function:Protein kinase that act on both serine and threonine residues.,PTM:Autophosphorylated. Isoform B is activated by phosphorylation by PKA.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex.,
Cytoplasm. Nucleus. Membrane. The truncated form (MST3/N) translocates to the nucleus. Colocalizes with STK38L in the membrane.
Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex.
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