catalytic activity:ATP = 3',5'-cyclic AMP + diphosphate.,cofactor:Binds 2 magnesium ions per subunit.,enzyme regulation:Activated by calcium/calmodulin.,function:This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 2 guanylate cyclase domains.,
Cell membrane ; Multi-pass membrane protein . Basolateral cell membrane . Apical cell membrane . Cell junction, synapse . Cell projection, dendrite . Cell projection, axon . Cell junction, synapse, presynaptic cell membrane . Cell junction, synapse, postsynaptic density . Membrane raft . Membrane, coated pit . Cytoplasmic vesicle, clathrin-coated vesicle membrane . Membrane, caveola . Localized to dendritic arbors (By similarity). Monomeric N-glycosylated species localizes in membrane raft. In contrast, monomeric unglycosylated forms are enriched in clathrin-coated pits and vesicles. Dimers are also localized outside of membrane rafts. Membrane raft localization and integrity is indispensable for CCE-stimulated adenylate cyclase activity (By similarity). .
Detected in brain cortex (PubMed:1715695). Expressed in islet (PubMed:25403481).
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