AChE Polyclonal Antibody

catalytic activity:Acetylcholine + H(2)O = choline + acetate.,disease:Behaves as an amyloid-promoting factor to promote the formation of amyloid plaques in Alzheimer disease.,function:Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.,online information:Acetylcholinesterase entry,online information:Blood group antigen gene mutation database,polymorphism:ACHE is responsible for the Yt blood group system. The molecular basis of the Yt(a)=Yt1/Yt(b)=Yt2 blood group antigens is a single variation in position 353; His-353 corresponds to Yt(a) and the rare variant with Asn-353 to Yt(b).,similarity:Belongs to the type-B carboxylesterase/lipase family.,subcellular location:Only observed in apoptotic nuclei.,subunit:Interacts with PRIMA1. The interaction with PRIMA1 is required to anchor it to the basal lamina of cells and organize into tetramers (By similarity). Isoform H generates GPI-anchored dimers; disulfide linked. Isoform T generates multiple structures, ranging from monomers and dimers to collagen-tailed and hydrophobic-tailed forms, in which catalytic tetramers are associated with anchoring proteins that attach them to the basal lamina or to cell membranes. In the collagen-tailed forms, isoform T subunits are associated with a specific collagen, COLQ, which triggers the formation of isoform T tetramers, from monomers and dimers. Isoform R may be monomeric.,tissue specificity:Isoform H is highly expressed in erythrocytes.,