cofactor:Binds 1 zinc ion per subunit.,function:May play an important role in the control of the immune response and during pregnancy.,induction:Induced during DC maturation and up-regulated in response to T-cell signals. In macrophage up-regulated by lipopolysaccharide (LPS). Up-regulated by 1 alpha, 25 dihydroxyvitamin D3 during differentiation of primary monocyte into macrophage.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 peptidase M12B domain.,tissue specificity:Expressed highly in the small intestine and appendix, moderately in lymph node, mucosal lining of the colon, thymus, spleen and very weakly in the bone marrow. Predominantly expressed in dendritic cells (DC) of the germinal center. Weakly expressed in monocyte and highly expressed in macrophage. Absent in immature DC.,
Secreted .
Expressed highly in the small intestine and appendix, moderately in lymph node, mucosal lining of the colon, thymus, spleen and very weakly in the bone marrow. Predominantly expressed in dendritic cells (DC) of the germinal center. Weakly expressed in monocyte and highly expressed in macrophage. Absent in immature DC.
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