catalytic activity:An alcohol + NAD(+) = an aldehyde or ketone + NADH.,cofactor:Binds 2 zinc ions per subunit.,cofactor:Zinc.,function:Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism.,miscellaneous:There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.,similarity:Belongs to the zinc-containing alcohol dehydrogenase family. Class-IV subfamily.,subunit:Homodimer.,tissue specificity:Preferentially expressed in stomach.,
Cytoplasm.
Preferentially expressed in stomach.
下载说明书
