cofactor:FAD. Binds 6-hydroxy-FAD non-covalently.,function:Oxidoreductase, which may play a role in mediating a TP53/p53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest.,induction:Expression detected at 4 hours after induction by TP53/p53. Down-regulated in a wide range of human tumors.,similarity:Belongs to the FAD-dependent oxidoreductase family.,tissue specificity:Detected in most normal tissues as two transcripts of 1.8 and 4.0 kb in length, respectively. Highly expressed in heart, moderately in liver and skeletal muscles, and expressed at low levels in placenta, lung, kidney, and pancreas. Both transcripts expressed following TP53/p53 induction. The shorter 1.8 kb transcript seems to be the major transcript in EB1 colon cancer cells.,
Lipid droplet . Cell membrane ; Lipid-anchor . Cytoplasm . Mitochondrion membrane . Nucleus .
Detected in most normal tissues as two transcripts of 1.8 and 4.0 kb in length, respectively. Highly expressed in heart, moderately in liver and skeletal muscles, and expressed at low levels in placenta, lung, kidney, and pancreas. Both transcripts expressed following p53/TP53 induction. The shorter 1.8 kb transcript seems to be the major transcript in EB1 colon cancer cells.
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