disease:Defects in MIP are a cause of autosomal recessive congenital cataract [MIM:154050].,domain:Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).,function:Water channel. May be responsible for regulating the osmolarity of the lens.,similarity:Belongs to the MIP/aquaporin (TC 1.A.8) family.,tissue specificity:Major component of lens fiber gap junctions.,
Cell membrane ; Multi-pass membrane protein . Cell junction, gap junction .
Expressed in the cortex and nucleus of the retina lens (at protein level) (PubMed:30790544). Major component of lens fiber gap junctions (PubMed:24120416).
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