caution:Was originally (PubMed:10704287) termed ARFGAP1.,developmental stage:Expressed at higher level in adult thymus, brain and lung, than in corresponding fetal tissues. Expressed at lower level in spleen, heart, kidney and liver during development.,enzyme regulation:GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2).,function:GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes.,similarity:Contains 1 Arf-GAP domain.,subcellular location:Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment.,tissue specificity:Widely expressed. Highest expression in endocrine glands (pancreas, pituary gland, salivary gland, and prostate) and testis with a much higher expression in the testis than in the ovary.,
Cytoplasm . Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side . Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment.
Widely expressed. Highest expression in endocrine glands (pancreas, pituitary gland, salivary gland, and prostate) and testis with a much higher expression in the testis than in the ovary.
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