function:Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter.,similarity:Contains 1 PH domain.,similarity:Contains 1 Rho-GAP domain.,subcellular location:Mainly cytoplasmic. Some fraction is nuclear.,subunit:Interacts with VEZF1.,
Cytoplasm . Nucleus . Mainly cytoplasmic. Some fraction is nuclear (By similarity). .
Brain,Erythroleukemia,Lung,
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