protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, induction of apoptosis, intracellular signaling cascade, protein kinase cascade, I-kappaB kinase/NF-kappaB cascade, mesoderm development, induction of apoptosis by extracellular signals, regulation of cell death, positive regulation of cell death,induction of programmed cell death, phosphorylation, peptidyl-tyrosine phosphorylation, peptidyl-tyrosine modification, calcium-mediated signaling, second-messenger-mediated signaling, developmental maturation,regulation of apoptosis, positive regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, cell maturation,
Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. In steady state, BTK is predominantly cytosolic. Following B-cell receptor (BCR) engagement by antigen, translocates to the plasma membrane through its PH domain. Plasma membrane localization is a critical step in the activation of BTK. A fraction of BTK also shuttles between the nucleus and the cytoplasm, and nuclear export is mediated by the nuclear export receptor CRM1.
Predominantly expressed in B-lymphocytes.
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