function:Functions as a negative regulator of AP-1 mediated transcription by binding to Jun proteins. Jun/B-ATF heterodimers bind DNA preferentially at the 12-O-tetradecanoylphorbol-13-acetate response element (TRE) (consensus: 5'-TGA[CG]TCA-3') and weaker at the cAMP-responsive region (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), but are transcriptionally inert.,PTM:Phosphorylated.,similarity:Belongs to the bZIP family.,similarity:Contains 1 bZIP domain.,subunit:Forms heterodimers with JUN, JUNB and JUND. Also interacts with IFI35.,tissue specificity:Expressed at highest levels in lung, and at lower levels in placenta, liver, kidney, spleen, and peripheral blood. Detected in SW480 colorectal cancer cell line and several hematopoietic tumor cell lines, including Raji Burkitt's lymphoma. Strongly expressed in mature B- and T-lymphocytes. According to PubMed:10777209 also expressed in moderate levels in lymph node and appendix and at low levels in thymus and bone marrow.,
Nucleus . Cytoplasm . Present in the nucleus and cytoplasm, but shows increased nuclear translocation after activation of T-cells. .
Expressed at highest levels in lung, and at lower levels in placenta, liver, kidney, spleen, and peripheral blood. Detected in SW480 colorectal cancer cell line and several hematopoietic tumor cell lines, including Raji Burkitt's lymphoma. Strongly expressed in mature B- and T-lymphocytes. Also expressed in moderate levels in lymph node and appendix and at low levels in thymus and bone marrow (PubMed:10777209).
下载说明书
