function:Receptor for CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Predominantly expressed in heart. Lower expression in lung, pancreas, spleen, colon, skeletal muscle and small intestine.,
Early endosome . Recycling endosome . Cell membrane ; Multi-pass membrane protein . Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.
Predominantly expressed in heart. Lower expression in lung, pancreas, spleen, colon, skeletal muscle and small intestine.
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