function:Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated. Phosphorylation on Ser-560 occurs specifically during mitosis.,similarity:Belongs to the APC6/CDC16 family.,similarity:Contains 7 TPR repeats.,subcellular location:Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle.,subunit:The APC/C is composed of at least 11 subunits. Interacts with PPP5C and CDC20.,
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle . Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle.
Aorta endothelial cell,Brain,Epithelium,Lung,Skin,
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