domain:The CRIB domain mediates interaction with CDC42.,function:Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner.,similarity:Belongs to the BORG/CEP family.,similarity:Contains 1 CRIB domain.,subunit:Interacts with RHOQ and CDC42 in a GTP-dependent manner, and with SEPT7.,tissue specificity:Highly expressed in the heart. Weakly expressed in the pancreas and liver.,
Endomembrane system ; Peripheral membrane protein . Cytoplasm, cytoskeleton .
Highly expressed in the heart. Weakly expressed in the pancreas and liver.
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