disease:Haploinsufficiency of CLIP2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS) [MIM:194050]. WBS is a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.,function:Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operates in the control of brain-specific organelle translocations.,similarity:Contains 2 CAP-Gly domains.,subcellular location:Associated with the cytoskeleton.,subunit:Interacts with CLASP1 and CLASP2.,
Cytoplasm . Cytoplasm, cytoskeleton . Localizes preferentially to the ends of tyrosinated microtubules. .
Brain,Clones donated by Kazusa DNA Research Inst.,Epitheliu
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