function:May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings.,PTM:Fatty acylated. Heavily palmitoylated in the cysteine string motif.,similarity:Contains 1 J domain.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,tissue specificity:Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart.,
Cytoplasm, cytosol . Membrane ; Lipid-anchor . Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane . Melanosome . Cell membrane . The association with membranes is regulated by palmitoylation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). .
Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart.
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