function:Corepressor targeting diverse transcription regulators. Isoform 2 probably acts as a scaffold for specialized synapses.,PTM:Isoform 2 is phosphorylated upon DNA damage, probably by ATM or ATR at Thr-179; Ser-181 and Ser-185. Phosphorylation by HIPK2 on Ser-428 induces proteasomal degradation.,similarity:Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.,subunit:Interacts with the C-terminus of adenovirus E1A protein. Can form homodimers or heterodimers of CTBP1 and CTBP2. Interacts with HIPK2 (By similarity). Interacts with PNN, NRIP1 and WIZ.,tissue specificity:Ubiquitous. Highest levels in heart, skeletal muscle, and pancreas.,
Nucleus . Cell junction, synapse .
Ubiquitous. Highest levels in heart, skeletal muscle, and pancreas.
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