catalytic activity:4-nitrophenol + NADPH + O(2) = 4-nitrocatechol + NADP(+) + H(2)O.,cofactor:Heme group.,function:Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.,induction:By ethanol and isoniazid.,online information:CYP2E1 alleles,online information:CYP2E1 entry,similarity:Belongs to the cytochrome P450 family.,
Endoplasmic reticulum membrane ; Peripheral membrane protein . Microsome membrane ; Peripheral membrane protein . Mitochondrion inner membrane ; Peripheral membrane protein . Post-translationally targeted to mitochondria. TOMM70 is required for the translocation across the mitochondrial outer membrane. After translocation into the matrix, associates with the inner membrane as a membrane extrinsic protein. .
Brain,Liver,Lung,PCR rescued clones,
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