DBH Polyclonal Antibody

catalytic activity:3,4-dihydroxyphenethylamine + ascorbate + O(2) = noradrenaline + dehydroascorbate + H(2)O.,cofactor:Binds 1 PQQ per subunit.,cofactor:Binds 2 copper ions per subunit.,disease:Defects in DBH are the cause of DBH deficiency [MIM:223360]; also called norepinephrine deficiency or noradrenaline deficiency. This disorder is characterized by profound deficits in autonomic and cardiovascular function, but apparently only subtle signs, if any, of central nervous system dysfunction.,function:Conversion of dopamine to noradrenaline.,induction:Activity is enhanced by nerve growth factor (in superior cervical ganglia and adrenal medulla). Trans-synaptic stimulation with reserpine, acetylcholine and glucocorticoids.,online information:Dopamine beta hydroxylase entry,pathway:Catecholamine biosynthesis; norepinephrine biosynthesis; norepinephrine from dopamine: step 1/1.,polymorphism:There are two main alleles of DBH: DBH-A with Ala-318 and DBH-B with Ser-318.,similarity:Belongs to the copper type II ascorbate-dependent monooxygenase family.,similarity:Contains 1 DOMON domain.,subunit:Homotetramer composed of two non-covalently bound disulfide-linked dimers.,