disease:DDX3Y is deleted in severe non-obstructive hypospermatogenesis [MIM:400042].,function:Probable ATP-dependent RNA helicase. May play a role in spermatogenesis.,similarity:Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,subcellular location:Shuttles between the nucleus and the cytoplasm in an XPO1-dependent manner.,subunit:May interact with TDRD3.,tissue specificity:Testis-specific. Expressed predominantly in spermatogonia.,
Cytoplasm . Nucleus . Shuttles between the nucleus and the cytoplasm in an XPO1-dependent manner.
Widely expressed at the mRNA level, with highest levels in testis (PubMed:9381176). Testis-specific (at protein level). Expressed predominantly in spermatogonia, but occasionally detected in some pre-leptotene/leptotene spermatocytes (PubMed:15294876).
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