PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Sequence of unknown origin in the C-terminal part.,similarity:Belongs to the formin homology family. Cappuccino subfamily.,similarity:Contains 1 FH1 (formin homology 1) domain.,similarity:Contains 1 FH2 (formin homology 2) domain.,tissue specificity:Expressed almost exclusively in the developing and mature central nervous system.,
Cytoplasm, cytoskeleton . Cytoplasm, cytosol . Cytoplasm, perinuclear region . Nucleus . Nucleus, nucleolus . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cell cortex . Colocalizes with the actin cytoskeleton (PubMed:20082305). Recruited to the membranes via its interaction with SPIRE1 (By similarity). Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion (By similarity). Accumulates in the nucleus following DNA damage (PubMed:26287480). .
Expressed almost exclusively in the developing and mature central nervous system.
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