cell motion, cell-substrate junction assembly, cell adhesion, cell-matrix adhesion, cell surface receptor linked signal transduction, integrin-mediated signaling pathway, response to extracellular stimulus, cell migration, regulation of cell-cell adhesion, positive regulation of cell-cell adhesion, biological adhesion, cell projection organization, cell projection assembly, microspike assembly, regulation of cell adhesion, cell-substrate adhesion, cellular response to extracellular stimulus, cell adhesion mediated by integrin, cell junction assembly, cell junction organization, odontogenesis of dentine-containing tooth, odontogenesis, fat cell differentiation, positive regulation of cell adhesion, filopodium assembly, cell motility, brown fat cell differentiation, leukocyte migration, localization of cell,
Cell membrane ; Single-pass type I membrane protein . Cell membrane ; Lipid-anchor .
Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney). Processed integrin alpha-6: Expressed at low levels in normal prostate tissue with elevated levels in prostate cancer tissue (at protein level) (PubMed:15023541).
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