function:Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence.,similarity:Belongs to the IAN GTP-binding protein family.,tissue specificity:Widely expressed with high levels in lymph node and spleen. High expression found in CD4 and CD8-positive T-cells and monocytes with very low levels in B-lymphocytes. Highly expressed in B-lymphocyte-derived neoplasms.,
Lysosome membrane ; Single-pass type IV membrane protein . Endosome, multivesicular body membrane ; Single-pass type IV membrane protein . Endosome membrane ; Single-pass type IV membrane protein . The mitochondrial localization originally reported was observed with C-terminally tagged protein and was not confirmed in later publications. .
Widely expressed with high levels in lymph node and spleen (PubMed:14724691). High expression found in T lymphocytes, including CD4 and CD8-positive T-cells, and monocytes (PubMed:14724691, PubMed:29382851). Very low expression levels in B-lymphocytes (PubMed:14724691).
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