disease:It is a candidate for certain defects in non-insulin-dependent diabetes mellitus (NIDDM). The variant in position 40 (Ser) is found in some NIDDM patients, but also in nondiabetic subjects.,function:This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.,similarity:Belongs to the G-protein coupled receptor 2 family.,
Cell membrane ; Multi-pass membrane protein . Is rapidly internalized after ligand-binding. .
Liver,Placenta,
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