function:Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF through replacement of GDP with GTP.,similarity:Contains 1 PH domain.,similarity:Contains 1 SEC7 domain.,subunit:Binds via its PH domain to the inositol head group of phosphotidylinositol 3,4,5-triphosphate with high affinity. Interacts with GRASP.,tissue specificity:Almost absent from liver, thymus and peripheral blood lymphocytes.,
Cytoplasm, cytosol. Cell membrane ; Peripheral membrane protein . Cell junction, adherens junction . Cell junction, tight junction . Translocates from the cytosol to membranes enriched in phosphatidylinositol 3,4,5-trisphosphate. .
Almost absent from liver, thymus and peripheral blood lymphocytes.
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