catalytic activity:Acetyl-CoA + histone = CoA + acetylhistone.,function:May play a role in telomeric silencing. Acetylates soluble but not nucleosomal H4 at 'Lys-5' and 'Lys-12' and acetylates histone H2A at 'Lys-5'. HAT1 has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG.,online information:Histone acetyltransferase entry,similarity:Belongs to the HAT1 family.,subcellular location:Nuclear in S-phase cells and cytoplasmic.,subunit:Heteromer of HAT1 and p46/HAT2 subunits.,
[Isoform A]: Nucleus matrix . Mitochondrion .; [Isoform B]: Cytoplasm . Nucleus . Nucleus matrix . Nucleus, nucleoplasm . Localization is predominantly nuclear in normal cells. Treatment with hydrogen peroxide or ionizing radiation enhances nuclear localization through redistribution of existing protein. .
Brain,Epithelium,Lung,Testis,
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