HoxD10 Polyclonal Antibody

developmental stage:Expressed in the developing limb buds.,disease:Defects in HOXD10 are a cause of congenital vertical talus (CVT) [MIM:192950]; also known as "rocker-bottom foot" deformity or congenital convex pes valgus. CVT is a dislocation of the talonavicular joint, with rigid dorsal dislocation of the navicular over the neck of the talus. This condition is usually associated with multiple other congenital deformities and only rarely is an isolated deformity.,function:Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.,similarity:Belongs to the Abd-B homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,tissue specificity:Strongly expressed in the adult male and female urogenital tracts.,