caution:Was originally (PubMed:7970704) thought to be the IK factor, a cytokine involved in the negative regulatory pathway of constitutive MHC class II antigens expression.,developmental stage:Expressed at similar levels in fetal and adult tissues.,function:Not known. May bind to chromatin.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the RED family.,tissue specificity:Ubiquitous.,
Nucleus . Nucleus, nucleoplasm . Chromosome . Cytoplasm, cytoskeleton, spindle pole . Predominantly present throughout the nucleoplasm during prometaphase, metaphase and anaphase. Is also detected in nuclear foci that are not identical with Cajal bodies. Starts to accumulate at chromosomes during telophase, and is nearly exclusively associated with chromosomes in newly divided cells (PubMed:24252166). Colocalizes with MAD1L1 at mitotic spindle poles during metaphase and anaphase (PubMed:22351768). .
Ubiquitous.
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