domain:Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.,function:Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.,induction:Upon contact with CD8(+)CD28(-) alloantigen-specific T suppressor (Ts) cells.,PTM:Phosphorylated.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Ligand binding leads to internalization and translocation to an antigen-processing compartment.,subunit:Binds PTPN6 when phosphorylated.,tissue specificity:Detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells.,
Cell membrane ; Single-pass type I membrane protein . Ligand binding leads to internalization and translocation to an antigen-processing compartment. .
Detected on monocytes, macrophages, dendritic cells, natural killer cells and B-cells (at protein level). Expressed in the lung.
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