function:Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance.,similarity:Belongs to the inward rectifier-type potassium channel family.,subunit:Seems to form heterodimer with Kir4.1/KCNJ10 or Kir2.1/KCNJ2.,tissue specificity:Highly expressed in kidney, pancreas and thyroid gland.,
Membrane ; Multi-pass membrane protein. Basolateral cell membrane . In kidney distal convoluted tubules, located in the basolateral membrane in the presence of KCNJ10. .
Widely expressed, with highest levels in adult and fetal kidney (at protein level). In the kidney, expressed in the proximal and distal convoluted tubules, but not in glomeruli nor collecting ducts.
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