domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,domain:The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.,function:Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.,similarity:Belongs to the potassium channel family. C (Shaw) subfamily.,subunit:Heteromultimer with KCNG3, KCNG4 and KCNV2.,
Cell membrane ; Multi-pass membrane protein . Cell projection, axon . Cell junction, synapse, presynaptic cell membrane . Localizes in parallel fiber membranes, distributed on the perisynaptic and extrasynaptic membranes away from the active zones. .
PCR rescued clones,
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