cofactor:Binds 1 4Fe-4S cluster. The cluster is not important for the catalytic activity, but which is probably involved in the proper positioning of the enzyme along the DNA strand.,disease:Defects in MUTYH are a cause of autosomal recessive colorectal adenomatous polyposis [MIM:608456].,disease:Defects in MUTYH are a cause of gastric cancer [MIM:137215].,function:Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.,similarity:Belongs to the nth/mutY family.,similarity:Contains 1 nudix hydrolase domain.,
Nucleus . Mitochondrion .
Kidney,
下载说明书
