function:Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).,PTM:The uncleaved signal sequence is required for efficient membrane targeting and proper membrane integration.,similarity:Belongs to the sodium/potassium/calcium exchanger family. SLC24A subfamily.,tissue specificity:Found only in the outer segments of retinal rod photoreceptors.,
Cell membrane ; Multi-pass membrane protein .
Expressed in the retina, particularly in the inner segment, outer and inner nuclear layers, and ganglion cell layer.
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