Nectin 4 Polyclonal Antibody

function:Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with PVRL2/nectin-1. Does not act as receptor for alpha-herpesvirus entry into cells.,PTM:The soluble form is produced by proteolytic cleavage at the cell surface (shedding), probably by ADAM17/TACE.,similarity:Belongs to the nectin family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Colocalizes with MLLT4 at cadherin-based adherens junctions.,subcellular location:The secreted form is found in breast tumor patients.,subunit:Self-associates. Interacts via its Ig-like V-type domain with PVRL1/nectin-1 Ig-like V-type domain. Interacts via its C-terminus with MLLT4.,tissue specificity:Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma.,