disease:A chromosomal aberration involving NR4A3 is a cause of a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with TAF2N.,disease:A chromosomal aberration involving NR4A3 is a cause of Ewing sarcoma [MIM:133450]. Translocation t(9;22)(q22-31;q11-12) with EWS.,function:Binds to the B1A response-element.,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR4 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,tissue specificity:High expression of isoform alpha in skeletal muscle. High expression of isoform beta in skeletal muscle and low expression in fetal brain and placenta.,
Nucleus .
Isoform alpha is highly expressed in skeletal muscle. Isoform beta is highly expressed in skeletal muscle and low expressed in fetal brain and placenta.
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