caution:It is uncertain whether Met-1 or Met-17 is the initiator.,disease:Defects in SLC22A18 are associated with breast cancer [MIM:114480].,disease:Defects in SLC22A18 are associated with lung cancer [MIM:211980].,disease:Defects in SLC22A18 are the cause of rhabdomyosarcoma type 1 (RMS1) [MIM:268210]. Rhabdomyosarcoma is a malignant tumor (sarcoma) derived from striated muscle.,function:May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney.,similarity:Belongs to the major facilitator superfamily. Organic cation transporter family.,subcellular location:Localized at the apical membrane surface of renal proximal tubules.,subunit:Interacts with RNF167.,tissue specificity:Expressed at high levels in adult and fetal kidney and liver, and adult colon. Expressed in fetal renal proximal tubules (at protein level). Expressed at lower levels in heart, brain and lung.,
Apical cell membrane ; Multi-pass membrane protein . Localized at the apical membrane surface of renal proximal tubules. .
Expressed at high levels in adult and fetal kidney and liver, and adult colon. Expressed in fetal renal proximal tubules (at protein level). Expressed at lower levels in heart, brain and lung.
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