disease:Defects in CDKN2C are involved in tumor formation.,function:Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.,similarity:Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.,similarity:Contains 4 ANK repeats.,subunit:Heterodimer of p18 with CDK6.,tissue specificity:Highest levels found in skeletal muscle. Also found in pancreas and heart.,
nucleus,cytoplasm,cytosol,
Highest levels found in skeletal muscle. Also found in pancreas and heart.
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