disease:Defects in SESN1 may be involved in heterotaxia. Heterotaxia is an aetiologically heterogeneous condition caused by an abnormal left-right axis formation, resulting in reversed left-right polarity of one or more organ systems.,function:Involved in the reduction of peroxiredoxins. May also be regulator of cellular growth.,induction:Isoforms T2 and isoform T3 are induced by genotoxic stress (UV, gamma-irradiation and cytotoxic drugs) in a p53-dependent manner. Isoform T1 is not induced by p53.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the sestrin family.,tissue specificity:Widely expressed.,
Nucleus . Cytoplasm .
Widely expressed.