Pax-9 Polyclonal Antibody

disease:Defects in PAX9 are a cause of oligodontia [MIM:604625]. It is a form of familial or selective tooth agenesis. Oligodontia is defined as the agenesis of 6 or more permanent teeth without associated systemic disorders. Agenesis of one or more teeth constitutes one of the most common developmental anomalies in man. Reported incidences vary from 1.6% to 9.6%, excluding third molar (Wisdom tooth) agenesis, which occurs in 20% of the population.,function:Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.,similarity:Contains 1 paired domain.,subunit:Interacts with KDM5B.,