function:Involved in epithelial differentiation and contributes to epidermal integrity and barrier formation.,PTM:Substrate of transglutaminase (in vitro).,subcellular location:In undifferentiated keratinocytes expressed in speckle-type nuclear granules and at the nuclear membrane, but in the differentiated keratinocytes colocalized with periplakin at the cell periphery and at cell-cell junctions.,subunit:Homodimer. Interacts with PPL.,tissue specificity:Ubiquitous.,
Nucleus . Cytoplasm . Chromosome . In undifferentiated keratinocytes expressed in speckle-type nuclear granules and at the nuclear membrane, but in the differentiated keratinocytes colocalized with periplakin at the cell periphery and at cell-cell junctions (PubMed:12853457). Localizes to chromatin (PubMed:26022416). .
Ubiquitous.
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