function:The interaction with Sm proteins inhibits their assembly on U RNA and interferes with snRNP biogenesis. Inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. May participate in cellular volume control by activation of a swelling-induced chloride conductance pathway.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the pICln family.,subcellular location:A small fraction is also associated with the cytoskeleton.,subunit:Homooligomer. Component of the methylosome, a 20S complex containing SKB1. Interacts with Sm proteins.,
Cytoplasm, cytosol . Nucleus . Cytoplasm, cytoskeleton . A small fraction is also associated with the cytoskeleton (PubMed:18984161).
Cervix carcinoma,Colon cancer,Colon carcinoma,Embryonic kid
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