function:The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). In case of HIV-1 infection, suppresses Tat-mediated transactivation.,PTM:Sumoylated by UBE2I in response to MEKK1-mediated stimuli.,similarity:Belongs to the AAA ATPase family.,subunit:May form a heterodimer with a related family member. Interacts with PAAF1. Interacts with HIV-1 Tat.,
Cytoplasm . Nucleus . Colocalizes with TRIM5 in the cytoplasmic bodies. .
Adipose tissue,Brain,Cajal-Retzius cell,Fetal brain cortex,Kidney,Lung,Peri
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