function:Mediates activation of NF-kappa-B. May play a role in T-cell activation.,PTM:Phosphorylated in vitro by OXSR1.,similarity:Belongs to the RELT family.,similarity:Contains 1 TNFR-Cys repeat.,subunit:Associates with TRAF1. Interacts with RELL1, RELL2 and OXSR1.,tissue specificity:Highest levels are in spleen, lymph node, thymus, peripheral blood leukocytes, bone marrow and fetal liver. Very low levels in skeletal muscle, testis and colon. Not detected in brain, kidney and pancreas.,
Cell membrane ; Single-pass type I membrane protein . Cytoplasm . Cytoplasm, perinuclear region .
Spleen, lymph node, brain, breast and peripheral blood leukocytes (at protein level) (PubMed:28688764). Expressed highly in bone marrow and fetal liver. Very low levels in skeletal muscle, testis and colon. Not detected in kidney and pancreas.
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