Renin Polyclonal Antibody

catalytic activity:Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.,disease:Defects in REN are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).,enzyme regulation:Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing.,function:Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.,online information:Renin entry,similarity:Belongs to the peptidase A1 family.,subcellular location:Associated to membranes via binding to ATP6AP2.,subunit:Interacts with ATP6AP2.,