cell adhesion, cell-matrix adhesion, cell surface receptor linked signal transduction, integrin-mediated signaling pathway, biological adhesion, cell projection organization, cell projection assembly, microspike assembly, cell-substrate adhesion, filopodium assembly,
Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction, hemidesmosome. Colocalizes with DST at the leading edge of migrating keratinocytes.
Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach.
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