function:Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation.,induction:In response to several B-cell activation signals.,PTM:Could be phosphorylated. Might be functionally regulated by protein kinase(s).,similarity:Contains 1 RGS domain.,tissue specificity:B-cell specific. Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin's lymphoma and hairy cell leukemia, expression is constitutively high.,
Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytosol .
Detected in peripheral blood monocytes (PubMed:10480894). Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high (PubMed:8473738).
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