Sec16A Polyclonal Antibody

function:Defines endoplasmic reticulum exit sites (ERES) and is required for secretory cargo trafic from the endoplasmic reticulum to the Golgi apparatus. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for normal transitional endoplasmic reticulum (tER) organization.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the SEC16 family.,subcellular location:SAR1A activity is required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation.,subunit:SEC16A and SEC16B are each present in multiple copies in a heteromeric complex. Interacts with SEC23A.,tissue specificity:Ubiquitous. Expressed at higher levels in the pancreas.,