domain:The PDZ domain-binding motif is involved in the interaction with INADL, CASK, APBA1, DLG1 and DLG4.,function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production.,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the G-protein coupled receptor 1 family.,subcellular location:Localizes to the post-synaptic thickening of axo-dendritic synapses.,subunit:Interacts with MPDZ and INADL. May interact with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2.,
Cell membrane ; Multi-pass membrane protein . Cell projection, dendrite . Cell projection, axon . Cytoplasmic vesicle . Membrane, caveola . Cell junction, synapse, presynapse .
Detected in brain cortex (at protein level). Detected in blood platelets.
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