SR-2C Polyclonal Antibody

domain:The PDZ domain-binding motif is involved in the interaction with MPDZ.,function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.,polymorphism:Position 23 is polymorphic; the frequencies in unrelated Caucasians are 0.87 for Cys and 0.13 for Ser.,PTM:N-glycosylated.,RNA editing:Partially edited. RNA editing generates receptor isoforms that differ in their ability to interact with the phospholipase C signaling cascade in a transfected cell line, suggesting that this RNA processing event may contribute to the modulation of serotonergic neurotransmission in the central nervous system.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with MPDZ.,